2016 Publications

Zhang Z, Li Y, Loh YR, Phoo WW, Hung AW, Kang C, Luo D.
Crystal structure of unlinked NS2B-NS3 protease from Zika virus​
Science. 2016 Dec 8. pii: aai9309. [Epub ahead of print]

Jin S, Sun J, Wunder T, Tang D, Cousins AB, Sze SK, Mueller-Cajar O, Gao YG.​
Structural insights into the LCIB protein family reveals a new group of ​β-carbonic anhydrases.
Proc Natl Acad Sci USA. 2016 Dec. pii: 201616294. [Epub ahead of print]

Phoo WW, Li Y, Zhang Z, Lee MY, Loh YR, Tan YB, Ng EY, Lescar J, Kang C, Luo D.
Structure of the NS2B-NS3 protease from Zika virus after self-cleavage.​
Nat Commun. 2016 Nov; 7:13410.​

Li Y, Wong YL, Lee MY, Li Q, Wang QY, Lescar J, Shi PY, Kang C.
Secondary Structure and Membrane Topology of the Full-Length Dengue Virus NS4B in Micelles​.
Angew Chem Int Ed Eng​l. 2016 Sep; 55(39):12068-72

Chua YD, Vinod KV, Oviya I, Wong SW, Nordenskiöld L, Plitzko JM, Danev R, Sandin S.
Phase-plate cryo-EM structure of the nucleosome core particle at near-atomic resloution.
Nucleic Acids Res. 2016 Sep 30;44(17):8013-9.​

Tay MY, Smith K, Ng IH, Chan KW, Zhao Y, Ooi EE, Lescar J, Luo D, Jans DA, Forwood JK, Vasudevan SG.
The C-terminal 18 Amino Acid Region of Dengue Virus NS5 Regulates its Subcellular Localization and Contains a Conserved Arginine Residue Essential for Infectious Virus Production​​.​​
PLoS Pathog. 2016 Sep; 12(9):e1005886.

Lim SP, Noble CG, Seh CC, Soh TS, El Sahili A, Chan GK, Lescar J, Arora R, Benson T, Nilar S, Manjunatha U, Wan KF, Dong H, Xie X, Shi PY, Yokokawa F.
Potent Allosteric Dengue Virus NS5 Polymerase Inhibitors: Mechanism of Action and Resistance Profiling.​​
PLoS Pathog. 2016 Aug;12(8):e1005737

Ludwig A, Nicholas BJ, Sandin S.​
Architecture of the caveolar coat complex.​​
J Cell Sci. 2016 Aug;129(16):3077-83.​​​

Ero R, Kumar V, Chen Y, Gao YG
​Similarity and diversity of translational GTPase factors EF-G, EF4, and BipA: From structure to function.
RNA Biol. 2016 Jun 20:1-16. 

Kumar V, Ero R, Ahmed T, Goh KJ, Zhan Y, Bhushan S, Gao YG
Structure of the GTP Form of Elongation Factor (EF4) Bound to the Ribosome.
J Biol Chem. 2016 Jun 17;291(25):12943-50​​

Zou S, Toh JD, Wong KH, Gao YG, Hong W, Woon EC​
N(6)-Methyladenosine: a conformational marker that regulates the substrate specifity of human demethylases FTO and ALKBH5.​
Sci Rep. 2016 May 9;6:25677​​

​Qian X, Hamid FM, El Sahili A, Darwis DA, Wong YH, Bhushan S, Makeyev EV, Lescar J.
Functional Evolution in Orthologous Cell-encoded RNA-dependent RNA Polymerases.​​​
J Biol Chem. 2016 Apr 22;291(17):9295-309​

​Vijaya Chandra SH,  Makhija H, Peter S, Myint Wai CM, Li J, Zhu J, Ren Z,  D'Alcontres MS, Siau JW, Chee S, Ghadessy FJ,  Dröge P
Sequence-specific Single-copy Transgenesis in Human LINE-1 Elements.
Nucleic Acids Res. 2016 Apr 7;44(6):e55.

Chaston JJ, Smits C,  Aragão D, Wong AS, Ahsan B, Sandin S, Molugu SK, Molugu SK, Bernal RA, Stock D, Stewart AG.
Structural and Functional Insights into the Evolution and Stress Adaptation of Type II Chaperonins.​​
Structure. 2016 Mar 1;24(3):364-74.​

Wu B, Huoh YS, Hur S.​
Measuring Monomer-to-Filament Transition of MAVS as an In Vitro Activity Assay for RIG-I-Like Receptors.​
Methods Mol Biol. 2016 Jan;1390:131-42.​​

Cheong VV, Heddi B, Lech CJ, Phan AT
Inverting the G-Tetrad Polarity of a G-Quadruplex by Using Xanthine and 8-Oxoguanine
Angew Chem Int Ed Engl. 2016 Jan;55(1):160-3.​