2017-18 Publications


Nucleic Acids Res. 2017 Dec 15;45(22):12904-12920. doi: 10.1093/nar/gkx1127.

NS3 helicase from dengue virus specifically recognizes viral RNA sequence to ensure optimal replication.

Swarbrick CMD1, Basavannacharya C1, Chan KWK1,2, Chan SA1, Singh D1, Wei N1, Phoo WW3,4, Luo D3, Lescar J4, Vasudevan SG1,2.

Trends Microbiol. 2017 Oct;25(10):797-808. doi: 10.1016/j.tim.2017.07.001. Epub 2017 Aug 5.

Zika Virus Protease: An Antiviral Drug Target.

Kang C1, Keller TH2, Luo D3.

Structure. 2018 Apr 3;26(4):555-564.e3. doi: 10.1016/j.str.2018.02.005. Epub 2018 Mar 8.

Structural Insights into the Inhibition of Zika Virus NS2B-NS3 Protease by a Small-Molecule Inhibitor.

Li Y1, Zhang Z2, Phoo WW3, Loh YR1, Li R1, Yang HY1, Jansson AE1, Hill J1, Keller TH1, Nacro K4, Luo D5, Kang C6.

Structure. 2017 Aug 1;25(8):1242-1250.e3. doi: 10.1016/j.str.2017.06.006. Epub 2017 Jul 6.

Structural Dynamics of Zika Virus NS2B-NS3 Protease Binding to Dipeptide Inhibitors.

Li Y1, Zhang Z2, Phoo WW3, Loh YR1, Wang W1, Liu S1, Chen MW2, Hung AW1, Keller TH1, Luo D4, Kang C5.

FEBS Lett. 2017 Aug;591(15):2338-2347. doi: 10.1002/1873-3468.12741. Epub 2017 Jul 20.

Structural characterization of the linked NS2B-NS3 protease of Zika virus.

Li Y1, Phoo WW2,3,4, Loh YR1, Zhang Z2,3, Ng EY1, Wang W1, Keller TH1, Luo D2,3, Kang C1.

Antiviral Res. 2017 Jul;143:38-47. doi: 10.1016/j.antiviral.2017.04.001. Epub 2017 Apr 5.

Chikungunya virus nsP4 RNA-dependent RNA polymerase core domain displays detergent-sensitive primer extension and terminal adenylyltransferase activities.

Chen MW1, Tan YB1, Zheng J2, Zhao Y1, Lim BT3, Cornvik T3, Lescar J2, Ng LFP4, Luo D5.

Nat Commun. 2017 Dec 7;8(1):1986. doi: 10.1038/s41467-017-02086-y.

Allosteric pyruvate kinase-based "logic gate" synergistically senses energy and sugar levels in Mycobacterium tuberculosis.

Zhong W1,2, Cui L1, Goh BC1,2, Cai Q3, Ho P1, Chionh YH1,4, Yuan M5,6, Sahili AE2,7, Fothergill-Gilmore LA5, Walkinshaw MD5, Lescar J8,9, Dedon PC10,11.

J Bacteriol. 2017 Nov 6. pii: JB.00515-17. doi: 10.1128/JB.00515-17. [Epub ahead of print]

Insights into biofilm dispersal regulation from the crystal structure of the PAS-GGDEF-EAL region of RbdA from Pseudomonas aeruginosa.

Liu C1, Liew CW2, Wong YH1,2, Tan ST1,2, Poh WH3,3, Manimekalai SMS1, Rajan S1,2, Xin L4, Liang ZX1, Grüber G1, Rice SA5,3, Lescar J4,2.

J Virol. 2017 Jun 21. pii: JVI.00406-17. doi: 10.1128/JVI.00406-17. [Epub ahead of print]

Structural mimicry of the dengue virus envelope glycoprotein revealed by the crystallographic study of an idiotype-anti-idiotype Fab complex.

Wong YH1, Goh BC1,2, Lim SY3, Teo EW3, Lim APC4, Dedon PC2,5, Hanson BJ4, MacAry PA6, Lescar J7,2.

Viruses. 2017 Apr 24;9(4). pii: E91. doi: 10.3390/v9040091.

Dengue Virus Non-Structural Protein 5.

El Sahili A1, Lescar J2.

J Am Chem Soc. 2017 Apr 19;139(15):5351-5358. doi: 10.1021/jacs.6b12637. Epub 2017 Mar 1.

Engineering a Catalytically Efficient Recombinant Protein Ligase.

Yang R1,2, Wong YH1,2, Nguyen GKT1, Tam JP1, Lescar J1,2, Wu B1,2.

J Biol Chem. 2018 Jan 5;293(1):100-111. doi: 10.1074/jbc.M117.815704. Epub 2017 Nov 16.

Structural analyses unravel the molecular mechanism of cyclic di-GMP regulation of bacterial chemotaxis via a PilZ adaptor protein.

Yan XF1,2, Xin L1, Yen JT1,2, Zeng Y3, Jin S1,2, Cheang QW1, Fong RACY1, Chiam KH3, Liang ZX4, Gao YG5,2,6.

Nat Commun. 2017 Nov 17;8(1):1575. doi: 10.1038/s41467-017-01680-4.

Nucleosome acidic patch-targeting binuclear ruthenium compounds induce aberrant chromatin condensation.

Davey GE1, Adhireksan Z1, Ma Z1, Riedel T2, Sharma D1, Padavattan S1, Rhodes D1,3,4, Ludwig A1, Sandin S1,3, Murray BS5, Dyson PJ6, Davey CA7,8.

Nucleus. 2017 May 4;8(3):275-278. doi: 10.1080/19491034.2017.1287643. Epub 2017 Feb 7.

Advances in phase plate cryo-EM imaging of DNA and nucleosomes.

Chua EYD1, Sandin S1,2.

J Struct Biol. 2017 Mar;197(3):350-353. doi: 10.1016/j.jsb.2017.01.002. Epub 2017 Jan 20.

Cryo-EM analysis of a domain antibody bound rotary ATPase complex.

Davies RB1, Smits C1, Wong ASW2, Stock D3, Christie M3, Sandin S4, Stewart AG5.