NISB Members

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Research Group

 

Professors 

 

 

Research Interest 

 

 

  • Application of NMR in protein structure, interactions and drug design. 

 

 

  • 3D structures of macromolecular protein complexes and their functions and mechanism. 

 

 

  • Nucleosome structure and stability, molecular recognition in chromatin and chromatin drug development. 

 

 

  • Biological and structural functions of DNA, RNA and human embryonic stem cell. 

 

 

  • Structure and function of ribosome, structure-based drug design, glycobiology towards biofuel and pathogen virulence. 

 

 

  • Structural biology, infectious diseases and structure-based drug design. 

 

 

  • Design, engineering, and development of hybrid nano/micro-scale devices from biological parts by utilizing protein engineering as assembly tool. 

 

 

  • Chemical biology of biopolymers. 

 

 

  • Mechanisms that establish and maintain apico-basal polarity of epithelial cells. Understanding how membrane compartmentalization controls cell polarity, on the cellular, molecular, and structural level. 

 

 

  • Study of the intracellular pathogenic RNA sensing and responding process. 

 

 

  • Molecular, physio-chemical, and structural principles from unique biological materials. 

 

  

  • ​Molecular dynamics simulation method and data analysis (AI and machine learning) method development to investigate protein-drug, RNA/DNA dynamics and folding mechanism, and DNA-protein and DNA-counterions interaction 

 

 

  • Biochemistry and mechanism of CO2-fixation related machinery. 

 

 

  • Chromatin biochemistry and biophysics: mechanisms and regulation of chromatin compaction. 

 

 

  • NMR development and applications. 

 

 

  • Combination of physical, chemical and computational methods to investigate and manipulate properties of biomolecules. 

 

 

  • Structure and function of chromatin and telomeres. 

 

 

  • Design and development of therapeutics, biologics and immunologics of anti-infectives and synthetic vaccines. 

 

 

  • Structural/functional dynamics of biological molecules, peptide/anti-microbial design and virtual screening. 

 

 

  • Combination of biochemical, structural and cellular approaches to study specific innate immune signaling pathways. 

 

Prof. Xing, Bengang 

 

  • Focusing on the interdisciplinary areas of Biomedical Fluorescent Imaging, Chemical Biology, Pharmaceutical Chemistry and Nano-medicine 

 

 

  • Apoptosis; Molecular chaperones in cancer, malaria, and neurodegenerative diseases; Peptidylprolyl cis-trans isomerase (PPIase); NMR; Structure-based drug design. 

 

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