NISB Members


Research Group





Research Interest 



  • Application of NMR in protein structure, interactions and drug design. 



  • 3D structures of macromolecular protein complexes and their functions and mechanism. 



  • Nucleosome structure and stability, molecular recognition in chromatin and chromatin drug development. 



  • Biological and structural functions of DNA, RNA and human embryonic stem cell. 



  • Structure and function of ribosome, structure-based drug design, glycobiology towards biofuel and pathogen virulence. 



  • Structural biology, infectious diseases and structure-based drug design. 



  • Design, engineering, and development of hybrid nano/micro-scale devices from biological parts by utilizing protein engineering as assembly tool. 



  • Chemical biology of biopolymers. 



  • Mechanisms that establish and maintain apico-basal polarity of epithelial cells. Understanding how membrane compartmentalization controls cell polarity, on the cellular, molecular, and structural level. 



  • Study of the intracellular pathogenic RNA sensing and responding process. 



  • Molecular, physio-chemical, and structural principles from unique biological materials. 



  • ​Molecular dynamics simulation method and data analysis (AI and machine learning) method development to investigate protein-drug, RNA/DNA dynamics and folding mechanism, and DNA-protein and DNA-counterions interaction 



  • Biochemistry and mechanism of CO2-fixation related machinery. 



  • Chromatin biochemistry and biophysics: mechanisms and regulation of chromatin compaction. 



  • NMR development and applications. 



  • Combination of physical, chemical and computational methods to investigate and manipulate properties of biomolecules. 



  • Structure and function of chromatin and telomeres. 



  • Design and development of therapeutics, biologics and immunologics of anti-infectives and synthetic vaccines. 



  • Structural/functional dynamics of biological molecules, peptide/anti-microbial design and virtual screening. 



  • Combination of biochemical, structural and cellular approaches to study specific innate immune signaling pathways. 


Prof. Xing, Bengang 


  • Focusing on the interdisciplinary areas of Biomedical Fluorescent Imaging, Chemical Biology, Pharmaceutical Chemistry and Nano-medicine 



  • Apoptosis; Molecular chaperones in cancer, malaria, and neurodegenerative diseases; Peptidylprolyl cis-trans isomerase (PPIase); NMR; Structure-based drug design.