2017 Publications


Swarbrick CMD, Basavannacharya C, Chan KWK, Chan SA, Singh D, Wei N, Phoo WW, Luo D, Lescar J, Vasudevan SG.

NS3 helicase from dengue virus specifically recognizes viral RNA sequence to ensure optimal replication.

Nucleic Acids Res. 2017 Dec 15;45(22):12904-12920. 



Zhong W, Cui L, Goh BC, Cai Q, Ho P, Chionh YH, Yuan M, Sahili AE, Fothergill-Gilmore LA, Walkinshaw MD, Lescar J, Dedon PC. 

Allosteric pyruvate kinase-based "logic gate" synergistically senses energy and sugar levels in Mycobacterium tuberculosis.

Nat Commun. 2017 Dec 7;8(1):1986. 



Kang C, Keller TH, Luo D. 

Zika Virus Protease: An Antiviral Drug Target.

Trends Microbiol. 2017 Oct;25(10):797-808. 



Li Y, Zhang Z, Phoo WW, Loh YR, Wang W, Liu S, Chen MW, Hung AW, Keller TH, Luo D, Kang C.

Structural Dynamics of Zika Virus NS2B-NS3 Protease Binding to Dipeptide Inhibitors. Structure.2017 Aug 1;25(8):1242-1250.



Li Y, Phoo WW, Loh YR, Zhang Z, Ng EY, Wang W, Keller TH, Luo D, Kang C.

Structural characterization of the linked NS2B-NS3 protease of Zika virus.

FEBS Lett. 2017 Aug;591(15):2338-2347



Chen MW, Tan YB, Zheng J, Zhao Y, Lim BT, Cornvik T, Lescar J, Ng LFP, Luo D.

Chikungunya virus nsP4 RNA-dependent RNA polymerase core domain displays detergent-sensitive primer extension and terminal adenylyltransferase activities.

Antiviral Res. 2017 Jul;143:38-47.



Wong YH, Goh BC, Lim SY, Teo EW, Lim APC, Dedon PC, Hanson BJ, MacAry PA, Lescar J.

Structural mimicry of the dengue virus envelope glycoprotein revealed by the crystallographic study of an idiotype-anti-idiotype Fab complex.

J Virol. 2017 Jun 21



El Sahili A, Lescar J.

Dengue Virus Non-Structural Protein 5.

Viruses. 2017 Apr 24;9(4). 



Yang R, Wong YH, Nguyen GKT, Tam JP, Lescar J, Wu B.

Engineering a Catalytically Efficient Recombinant Protein Ligase.

J Am Chem Soc. 2017 Apr 19;139(15):5351-5358.



Aw A, Gao X, Hao P, Gunalan K, Chu TT, Ameya S, Lescar J, Chandramohanadas R, Sze SK, Preiser PR.

RH5-Basigin interaction induces changes in the cytoskeleton of the host RBC.

 Cellular Microbiology 19(9) e12747 Apr 13



R.F.S. Lee, T. Riedel, S. Escrig, C. Maclachlan, G.W. Knott, C.A. Davey, K. Johnsson, A. Meibom & P.J. Dyson.

Differences in cisplatin distribution in sensitive and resistant ovarian cancer cells: a TEM/NanoSIMS study. 

Metallomics.  9(10): 1413-1420.



Ludwig, A., Nguyen, T.H., Leong, D., Ravi, L.I., Tan, B.H., Sandin, S. and Sugrue, R.J.

Caveolae provide a specialized membrane environment for respiratory syncytial virus assembly.

Journal of cell science, 130, 1037-1050.



Davey, G.E., Adhireksan, Z., Ma, Z., Riedel, T., Sharma, D., Padavattan, S., Rhodes, D., Ludwig, A., Sandin, S., Murray, B.S. et al.

Nucleosome acidic patch-targeting binuclear ruthenium compounds induce aberrant chromatin condensation.

Nature communications, 8, 1575.



Chua, E.Y.D. and Sandin, S.

Advances in phase plate cryo-EM imaging of DNA and nucleosomes.

Nucleus. 2017 May 4;8(3):275-278. doi: 10.1080/19491034.2017.1287643.



Ahmed T, Shi J, Bhushan S.

Unique localization of the plastid-specific ribosomal proteins in the chloroplast ribosome small subunit provides mechanistic insights into the chloroplastic translation.

Nucleic Acids Research. Aug 2017;45(14):8581-95.



Belousoff MJ, Eyal Z, Radjainia M, Ahmed T, Bamert RS, Matzov D, Bashan A, Zimmerman E, Mishra S, Cameron D, Elmlund H, Peleg AY, Bhushan S, Lithgow T, Yonath A.

Structural Basis for Linezolid Binding Site Rearrangement in the Staphylococcus aureus Ribosome.

MBio. 2017 May 9;8(3)



Wong CF, Shin J, Subramanian Manimekalai MS, Saw WG, Yin Z, Bhushan S, Kumar A, Ragunathan P, Grüber G.

AhpC of the mycobacterial antioxidant defense system and its interaction with its reducing partner Thioredoxin-C

Sci Rep. 2017 Jul 11;7(1):5159.



Nguyen TQN, Lim KW, Phan AT.

A Dual-Specific Targeting Approach Based on the Simultaneous Recognition of Duplex and Quadruplex Motifs.

Sci Rep. 2017 Sep 20;7(1):11969.



Adrian M, Winnerdy FR, Heddi B, Phan AT.

Rotation of Guanine Amino Groups in G-Quadruplexes: A Probe for Local Structure and Ligand Binding.

Biophys J. 2017 Aug 22;113(4):775-784.



Do NQ, Chung WJ, Truong THA, Heddi B, Phan AT.

G-quadruplex structure of an anti-proliferative DNA sequence.

Nucleic Acids Res. 2017 Jul 7;45(12):7487-7493.



Chen Q, Yang R, Korolev N, Liu CF, Nordenskiöld L.

Regulation of Nucleosome Stacking and Chromatin Compaction by the Histone H4 N-Terminal Tail-H2A Acidic Patch Interaction.

J Mol Biol. 2017 Jun 30;429(13):2075-2092